The Stamets Stack


The Stamets stack, coined by renowned mycologist Paul Stamets, is a microdosing protocol that pairs psilocybin mushrooms with Lion’s Mane mushroom and niacin. The combination promotes cognitive function, supports neuroplasticity and neural repair, and enhances the effects of psilocybin.

The first Stamets stack of the stack is Lion’s Mane (Hericium erinaceus). This medicinal mushroom contains compounds like herinacins and erinacines that stimulate nerve growth factor production, which can lead to improved cognition and mental health. It’s also believed to reduce aging-related mental decline by inhibiting serotonin receptors in the brain.

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Next is niacin, or vitamin B3. The stack’s niacin supplement is typically taken first to prime the system and facilitate absorption of other supplements. Niacin is known for its vasodilating qualities that cause a flushing sensation. This flushing allows niacin to effectively cross the blood-brain barrier and deliver psilocybin and Lion’s Mane deep into the neural extremities where neurogenesis occurs. Niacin also enhances the psychedelic experience by promoting feelings of euphoria, well-being, and increased connectivity with others.

It’s essential to seek out high-quality ingredients to ensure your niacin, lion’s mane, and psilocybin mushrooms are free from harmful pesticides and chemicals. Choosing organic products will help you avoid unnecessary toxins, as well as save money over time. Lastly, it’s important to start small and gradually increase your dosage. This way you can gauge your body’s response and ensure optimal results. As you embark on this journey, remember to prioritize quality, be cautious and respectful of your body, and stay curious!

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